IDRA-21 review | Everything about this potent Nootropic | 2020

This is a complete guide and review of IDRA-21, is a nootropic that has been getting a lot of popularity lately. IDRA-21 is very popular in the nootropic community because of how potent and similar to Aniracetam it is.

Let’s get started.

IDRA 21 Review

In this guide / review, you will find out everything that you need to know about IDRA-21, including:

  • What is it and how does it work
  • Is IDRA-21 legal in my country
  • Where to buy high-quality, pure IDRA-21
  • What are the benefits and side effects of taking this nootropic

We will answer all of these questions as well as go over other IDRA-21 topics such as the half-life, dosages, safety profile and more.

Before we begin, we need to ehmphasize a clear disclaimer. The information depicted in this article is purely for informational purposes only. You should consult your physician about medications and nutritional supplements. Please contact your healthcare professional before making any changes to your lifestyle.

With that being said, let’s dive right in by first explaining what IDRA-21 actually is.

What is IDRA-21

IDRA-21 is a positive allosteric modulator of the AMPA receptor and a benzothiadiazine derivative.

Animal studies have shown that it’s about 20-30 times as strong as Aniracetam  in reversing cognitive deficits.

The great this about IDRA-21 is that it produces long-lasting benefits that last up to 48 hours. Most other nootropics, such as GTS-21, for example, only produce effects that last for a few hours. Even nootropics that are one of the most long-lasting, such as 9-Me-BC, normally don’t last more than a day.

The reason for the long-lasting benefits it the long, 48 hour half-life which also means that users only need to take a dosage once every 2 days. 

How does it work

As an ampakine drug, IDRA-21 works through the positive allosteric modulation of the glutamate AMPA receptors in the brain. Since the AMPA receptors cause rapid synaptic transmission, there is an increase in the excitatory synaptic strength. It is also known as allosteric activation.

Is IDRA-21 legal

IDRA-21 is legal just like most other nootropics. As of 2020 it’s legal in every country in the world.

It’s classified and sold as a dietary supplement, which is regulated the same as foods. Foods are legally assumed “innocent” (i.e., safe) until proven guilty, so to speak.


The benefits of IDRA-21 are:

  • Significantly improved cognition and short-term memory
  • Increased mental focus
  • Therapeutic effects on depression
  • Significantly increased motivation

Side effects

The side effects of IDRA-21 are:

  • Nausea
  • Headaches
  • Moodswings
  • Dizziness

These side effects seem to be quite rare and most users don’t experience them. As long as you don’t go over the recommended dosages, you shouldn’t be seeing any of these side effects. At the end of the day, however, everybody reacts differently to nootropics such as IDRA-21.


IDRA-21 has a half-life of 48 hours.

This means that users only need to take a dosage once every 2 days.


As with almost all potent nootropics, you should always start at a low dosage and work your way up. This way you will see exactly how you react to IDRA-21.

Most users take a dosage of 10mg once every two days.

Keep in mind, however, that there have been no significant human trials done and because of that, we can’t really give a set dosage. You should probably start at small dosages and work your way up to a maximum dosage of 10mg per two days.

Where to buy IDRA-21

If you’re looking for a company that sells pure, high-quality IDRA-21 and other nootropics, take a look at

Most users buy it from them and rightfully so, their nootropics are all 3d party tested. All of their products are high-quality and I can vouch for that myself because I use their products.


In conclusion,

The bad thing about IDRA-21, however, is that there haven’t been any significant human trials done with it.

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