Glutathione Review, Benefits, Dosage, Side Effects | November 2021

Many people have never heard of Glutathione but it is one of the most important nootropics present in nearly every cell in the body.

As we’ll later see, Glutathione is so powerful of an antioxidant, it recycles other antioxidants in your body!

Glutathione Review

Glutathione deficiency has been linked to many diseases and cognitive problems, some of which we’ll address in this article.

This Glutathione review will show you exactly what it is, how it works, the best dosage to take, potential side effects and in the end, where to buy the best form of Glutathione.

What is Glutathione

Glutathione is a tripeptide created out of three main amino acids:

  • Cysteine
  • Glycine
  • Glutamic acid

The good news is that your body produces all three of the above, which means that Glutathione is created inside your body without outside interference.

This raises the question; why supplement with Glutathione when the body makes it on its own?

The answer is simple; as we age, Glutathione levels drop naturally and not just that, our poor diets contribute to lack of it in our body.

When the brain is concerned, Glutathione is a cognitive enhancer, antioxidant and neuroprotectant.

How Does It Work

We’ll go over how Glutathione works in the brain, since that’s our area of interest.

If free radicals amass unhindered in the brain, it causes inflammation and brain cell death.

Glutathione acts as a free radical antagonist in the brain, also known as an antioxidant.

Not only does it help your brain rid itself of oxidative stress, but it also revives Vitamin C and Vitamin E, which are also two very powerful antioxidants.

It also secures your brain against the byproduct of ATP, which are called Reactive Oxygen Species (ROS).

Whenever you produce energy in the brain, ROS get released and if left untreated, it can lead to oxidative stress.

Lastly, Glutathione helps with brain function by aiding in the fight against neurodegenerative diseases, like Alzheimer’s.

Is Glutathione Legal

It would be pointless to outlaw supplementation with something that’s produced naturally in the body.

Yes, you can buy Glutathione legally in every country of the world and you shouldn’t have any problems with customs.

There is one weird rule in Australia stating that Glutathione can’t be marketed for skin issues but other than that, it’s completely legal.

Glutathione Benefits

As previously mentioned, Glutathione is part of every cell in the body and its role is quintessential for the normal functioning of our body.

With that in mind, we’ll list some of the most important benefits of Glutathione.

1. Powerful Anxiolytic and Antidepressant

Generally speaking, people suffering from depression also have low Glutathione levels.

Raising those levels through supplementation could improve depressive symptoms.

There is also a link between anxiolytic drugs working wonders exactly because they are raising Glutathione levels.

2. Helps With ADHD Symptoms

People with ADHD suffer from high oxidative stress and low Glutathione levels in the brain.

Glutathione supplementation has been extensively studied and has so far yielded good results in clinical studies.

3. Neuroprotectant

As we age, diseases like Alzheimer’s and Parkinson’s are becoming more and more of a reality.

In fact, Glutathione is considered part of a preventative care routine against Parkinson’s disease and can improve memory and life quality for those susceptible to this disease

4. Longevity

When your cells lack Glutathione, they become susceptible to damage from free radicals.

Glutathione supplementation helps your cells slow down the aging process, which means less cell death and fewer brain cells lost.

In return, this leads to improved cognition even when we get on in years.

5. Helps With Addiction

Drugs and alcohol change the way our brain functions through increasing ROS.

Studies reveal that Glutathione can reverse the damage done by oxidative stress and help detoxify the body of drugs.

Glutathione Dosage

The perfect Glutathione dosage is 500mgs per day taken once in the morning.

This dosage ensures that you get the benefits you desire, without invoking too many side effects.

Similar dosages have been used in clinical studies and the conclusion has been that Glutathione is tolerated quite well by the body, as expected.

Glutathione Side Effects

When taken orally, Glutathione does have some minor side effects, including weight gain, flatulence and other digestive issues.

One rare side effect you should look out for is inflammation.

If the latter happens to you, it means you’ve roused your immune system and that you need to cut down on the dosage.

Split your Glutathione dosage in half and everything should soon return back to normal.

If the problem persists, immediately discontinue usage or consider using something similar, like NAC.

More on NAC below.

Glutathione VS NAC

NAC is a precursor to Glutathione which basically means that NAC is one of the building blocks of Glutathione.

NAC is often cited as being a more effective way to supplement with Glutathione.

However, things aren’t as black and white as they seem.

First of all, some people have very strong reactions to NAC and generally speaking, you’re more likely to experience side effects supplementing with NAC.

Not just that but Glutathione works faster in the body compared to NAC, since NAC has to first convert to Glutathione to have an effect on the brain.

There isn’t a clear winner between the two, some people respond better to NAC, others prefer Glutathione.

We suggest trying both and observing which compound yields the better results.

Be sure to check out our NAC review as well!

Where to Buy Glutathione

Glutathione on its own has poor bioavailability and gets broken down by the liver and digestive system before it reaches the bloodstream.

That’s why some people go as far as getting it intravenously into their body.

You won’t have to follow the same route as we have found a product by a vetted vendor of ours called S-Acetyl-L-Glutathione.

It might seem like a mouthful at first but it’s actually very simple: This is Glutathione that’s both acetylated (for better absorption) and liposomal (fat-soluble).

In return, you get a product that’s easily absorbed in the body!

Check out our recommended list of companies for pure S-Acetyl-L-Glutathione.


You can’t go wrong supplementing with Glutathione.

However, it’s questionable whether it would exert nootropic effects on young, healthy subjects.

All the research we currently have focuses on supplementing when there is a lack of Glutathione in the body.

All in all, this Glutathione review has shown us how low Glutathione levels can lead to disaster.

It’s entirely up to you to decide whether you need extra Glutathione in your body.

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